NuRD blocks reprogramming of mouse somatic cells into pluripotent stem cells.

  title={NuRD blocks reprogramming of mouse somatic cells into pluripotent stem cells.},
  author={Min Luo and Te Ling and Wenbing Xie and He Sun and Yonggang Zhou and Qiaoyun Zhu and Meili Shen and Le Zong and Guoliang Lyu and Yun Zhao and Tao Ye and Jun Gu and Wei Tao and Zhigang Lu and Ingrid Grummt},
  journal={Stem cells},
  volume={31 7},
Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) by overexpression of a defined set of transcription factors requires epigenetic changes in pluripotency genes. Nuclear reprogramming is an inefficient process and the molecular mechanisms that reset the epigenetic state during iPSC generation are largely unknown. Here, we show that downregulation of the nucleosome remodeling and deacetylation (NuRD) complex is required for efficient reprogramming. Overexpression of Mbd3… CONTINUE READING
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