NuRD Blocks Reprogramming of Mouse Somatic Cells into Pluripotent Stem Cells

@article{Luo2013NuRDBR,
  title={NuRD Blocks Reprogramming of Mouse Somatic Cells into Pluripotent Stem Cells},
  author={Min Luo and Te Ling and W. Xie and He Sun and Y. Zhou and Qiaoyun Zhu and Meili Shen and Le Zong and Guoliang Lyu and Yun Zhao and T. Ye and J. Gu and W. Tao and Zhigang Lu and I. Grummt},
  journal={STEM CELLS},
  year={2013},
  volume={31}
}
Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) by overexpression of a defined set of transcription factors requires epigenetic changes in pluripotency genes. Nuclear reprogramming is an inefficient process and the molecular mechanisms that reset the epigenetic state during iPSC generation are largely unknown. Here, we show that downregulation of the nucleosome remodeling and deacetylation (NuRD) complex is required for efficient reprogramming. Overexpression of Mbd3… Expand
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