NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Gα

@article{Voet2009NuMArelatedLA,
  title={NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Gα},
  author={Monique van der Voet and Christian W. H. Berends and Audrey Perreault and Tu Nguyen-Ngoc and Pierre G{\"o}nczy and Marc Vidal and Mike Boxem and S. A. F. A. van den Heuvel},
  journal={Nature Cell Biology},
  year={2009},
  volume={11},
  pages={269-277}
}
The spindle apparatus dictates the plane of cell cleavage, which is critical in the choice between symmetric or asymmetric division. Spindle positioning is controlled by an evolutionarily conserved pathway, which involves LIN-5/GPR-1/2/Gα in Caenorhabditis elegans, Mud/Pins/Gα in Drosophila and NuMA/LGN/Gα in humans. GPR-1/2 and Gα localize LIN-5 to the cell cortex, which engages dynein and controls the cleavage plane during early mitotic divisions in C. elegans. Here we identify ASPM-1… CONTINUE READING

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