NuMA localization, stability, and function in spindle orientation involve 4.1 and Cdk1 interactions

@inproceedings{Seldin2013NuMALS,
  title={NuMA localization, stability, and function in spindle orientation involve 4.1 and Cdk1 interactions},
  author={Lindsey Seldin and Nicholas D. Poulson and Henry P. Foote and Terry Lechler},
  booktitle={Molecular biology of the cell},
  year={2013}
}
The epidermis is a multilayered epithelium that requires asymmetric divisions for stratification. A conserved cortical protein complex, including LGN, nuclear mitotic apparatus (NuMA), and dynein/dynactin, plays a key role in establishing proper spindle orientation during asymmetric divisions. The requirements for the cortical recruitment of these proteins, however, remain unclear. In this work, we show that NuMA is required to recruit dynactin to the cell cortex of keratinocytes. NuMA's… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
22 Extracted Citations
32 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 22 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 32 references

Similar Papers

Loading similar papers…