NuMA and nuclear lamins behave differently in Fas-mediated apoptosis.

  title={NuMA and nuclear lamins behave differently in Fas-mediated apoptosis.},
  author={Pekka Taimen and Markku Kallajoki},
  journal={Journal of cell science},
  volume={116 Pt 3},
NuMA is a nuclear matrix protein that has an essential function in the organization of the mitotic spindle. Here we have studied the fate of NuMA in Fas-treated apoptotic Jurkat T and HeLa cells. We show that in both cell lines NuMA is an early target protein for caspases and that NuMA is cleaved coincidently with poly(ADP-ribose) polymerase-1 (PARP-1) and nuclear lamin B. NuMA is cleaved differently in Jurkat T and HeLa cells, suggesting that different sets of caspases are activated in these… CONTINUE READING


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