Ntf3 acts downstream of Sip1 in cortical postmitotic neurons to control progenitor cell fate through feedback signaling.

@article{Parthasarathy2014Ntf3AD,
  title={Ntf3 acts downstream of Sip1 in cortical postmitotic neurons to control progenitor cell fate through feedback signaling.},
  author={Srinivas Parthasarathy and Swathi Srivatsa and Anjana Nityanandam and Victor S Tarabykin},
  journal={Development},
  year={2014},
  volume={141 17},
  pages={3324-30}
}
Cortical progenitors undergo progressive fate restriction, thereby sequentially producing the different layers of the neocortex. However, how these progenitors precisely change their fate remains highly debatable. We have previously shown the existence of cortical feedback mechanisms wherein postmitotic neurons signal back to the progenitors and promote a switch from neurogenesis to gliogenesis. We showed that Sip1 (Zeb2), a transcriptional repressor, controls this feedback signaling. A similar… CONTINUE READING
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