Nrf2 transcriptionally activates the mafG gene through an antioxidant response element.

@article{Katsuoka2005Nrf2TA,
  title={Nrf2 transcriptionally activates the mafG gene through an antioxidant response element.},
  author={Fumiki Katsuoka and Hozumi Motohashi and James Douglas Engel and Masayuki Yamamoto},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 6},
  pages={4483-90}
}
Nrf2 accumulates in nuclei upon exposure to oxidative stress, heterodimerizes with a small Maf protein, and activates the transcription of stress target genes through antioxidant response elements (AREs). We found that diethyl maleate (DEM), a well known activator of Nrf2, induces one of the small Maf genes, mafG. To elucidate roles MafG might play in the oxidative stress response, we examined transcriptional regulation of the mouse mafG gene. MafG utilizes three independent first exons that… CONTINUE READING

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