Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia

@article{Wu2010Nrf2RA,
  title={Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia},
  author={Raymond P. Wu and Tomoko Hayashi and H. Cottam and Guangyi Jin and Shiyin Yao and Christine Wu and M. Rosenbach and M. Corr and R. Schwab and D. Carson},
  journal={Proceedings of the National Academy of Sciences},
  year={2010},
  volume={107},
  pages={7479 - 7484}
}
Recent studies show that redox-active small molecules are selectively cytotoxic to chronic lymphocytic leukemia (CLL). Although elevated levels of reactive oxygen species in CLL cells have been implicated, the molecular mechanism underlying this selectivity is unclear. In other cell types, the nuclear factor erythroid 2–related factor 2 (Nrf2) signaling pathway regulates the oxidative stress response. We found elevated Nrf2 signaling in untreated CLL cells compared with normal lymphocytes… Expand
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