Nrf2 regulates NGF mRNA induction by carnosic acid in T98G glioblastoma cells and normal human astrocytes.

@article{Mimura2011Nrf2RN,
  title={Nrf2 regulates NGF mRNA induction by carnosic acid in T98G glioblastoma cells and normal human astrocytes.},
  author={Junsei Mimura and Kunio Kosaka and Atsushi Maruyama and Takumi Satoh and Nobuhiko Harada and Hidemi Yoshida and Kei Satoh and Masayuki Yamamoto and Ken Itoh},
  journal={Journal of biochemistry},
  year={2011},
  volume={150 2},
  pages={209-17}
}
Nerve growth factor (NGF) is a neurotrophic factor that plays an important role in neuronal cell development and survival. Carnosic acid (CA), a hydrophobic constituent of the herb rosemary, induces NGF production in human T98G glioblastoma cells, but the mechanism through which it works remains unknown. In the present study, we found a redox-sensitive transcription factor, Nrf2, which coordinates the expression of cytoprotective phase 2 genes, also participates in CA-inducible NGF expression… CONTINUE READING
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