Nrf2-regulated PPAR{gamma} expression is critical to protection against acute lung injury in mice.

@article{Cho2010Nrf2regulatedPE,
  title={Nrf2-regulated PPAR\{gamma\} expression is critical to protection against acute lung injury in mice.},
  author={H Cho and Wesley Gladwell and Xuting Wang and Brian N. Chorley and Douglas A. Bell and Sekhar P. M. Reddy and Steven R. Kleeberger},
  journal={American journal of respiratory and critical care medicine},
  year={2010},
  volume={182 2},
  pages={170-82}
}
RATIONALE The NF-E2 related factor 2 (Nrf2)-antioxidant response element (ARE) pathway is essential for protection against oxidative injury and inflammation including hyperoxia-induced acute lung injury. Microarray expression profiling revealed that lung peroxisome proliferator activated receptor gamma (PPARgamma) induction is suppressed in hyperoxia-susceptible Nrf2-deficient (Nrf2(-/-)) mice compared with wild-type (Nrf2(+/+)) mice. PPARgamma has pleiotropic beneficial effects including… CONTINUE READING
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