Nrf2 protects against maladaptive cardiac responses to hemodynamic stress.

@article{Li2009Nrf2PA,
  title={Nrf2 protects against maladaptive cardiac responses to hemodynamic stress.},
  author={Jinqing Li and Tomonaga Ichikawa and Luis Villacorta and Joseph S Janicki and Gregory L. Brower and Masayuki Yamamoto and Taixing Cui},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2009},
  volume={29 11},
  pages={1843-50}
}
BACKGROUND Reactive oxygen species (ROS) play an important role in the maintenance of cardiovascular homeostasis. The present study sought to determine whether nuclear factor erythroid-2 related factor 2 (Nrf2), a master gene of the endogenous antioxidant defense system, is a critical regulator of the cardiac hypertrophic response to pathological stress. METHODS AND RESULTS Cardiac hypertrophy and dysfunction were established in mice by transverse aortic constriction (TAC). Nrf2 expression… CONTINUE READING