Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy.

@article{Ni2014Nrf2PT,
  title={Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy.},
  author={H Ni and Benjamin L. Woolbright and Jessica A R Williams and Bryan L. Copple and Wei Cui and James P. Luyendyk and Hartmut Jaeschke and Wenxing Ding},
  journal={Journal of hepatology},
  year={2014},
  volume={61 3},
  pages={617-25}
}
BACKGROUND & AIMS Autophagy is an intracellular lysosomal degradation process that plays an important role in regulating normal physiological functions of the liver. The purpose of the present study was to investigate the mechanism(s) by which the loss of hepatic autophagy leads to liver inflammation, fibrosis and tumorigenesis. METHODS Hepatocyte-specific Atg5 knockout mice were generated by crossing Atg5 Flox/Flox mice with albumin Cre mice. These mice were also crossed with Nrf2 knockout… CONTINUE READING

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