Nrf2 pathway activation contributes to anti-fibrosis effects of ginsenoside Rg1 in a rat model of alcohol- and CCl4-induced hepatic fibrosis

@inproceedings{Li2014Nrf2PA,
  title={Nrf2 pathway activation contributes to anti-fibrosis effects of ginsenoside Rg1 in a rat model of alcohol- and CCl4-induced hepatic fibrosis},
  author={Jian-ping Li and Yan Gao and Shi-feng Chu and Zhao Zhang and Cong-yuan Xia and Zheng Mou and Xiu-yun Song and Wen-bin He and Xiao-feng Guo and Nai-Hong Chen},
  booktitle={Acta Pharmacologica Sinica},
  year={2014}
}
Aim:To investigate the anti-fibrosis effects of ginsenoside Rg1 on alcohol- and CCl4-induced hepatic fibrosis in rats and to explore the mechanisms of the effects.Methods:Rats were given 6% alcohol in water and injected with CCl4 (2 mL/kg, sc) twice a week for 8 weeks. Rg1 (10, 20 and 40 mg/kg per day, po) was administered in the last 2 weeks. Hepatic… CONTINUE READING