Nrf2 modulates contractile and metabolic properties of skeletal muscle in streptozotocin-induced diabetic atrophy.

@article{Whitman2013Nrf2MC,
  title={Nrf2 modulates contractile and metabolic properties of skeletal muscle in streptozotocin-induced diabetic atrophy.},
  author={Samantha Averil Whitman and Min Hui Long and Georg T Wondrak and Hongting Zheng and Donna D. Zhang},
  journal={Experimental cell research},
  year={2013},
  volume={319 17},
  pages={
          2673-83
        }
}
The role of Nrf2 in disease prevention and treatment is well documented; however the specific role of Nrf2 in skeletal muscle is not well described. The current study investigated whether Nrf2 plays a protective role in an STZ-induced model of skeletal muscle atrophy. Modulation of Nrf2 through siRNA resulted in a more robust differentiation of C2C12s, whereas increasing Nrf2 with sulforaphane treatment inhibited differentiation. Diabetic muscle atrophy was not dramatically influenced by Nrf2… CONTINUE READING
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