Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis.

@article{Iida2004Nrf2IE,
  title={Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis.},
  author={Katsuyuki Iida and Ken Itoh and Yoshito Kumagai and Ryoichi Oyasu and Kazunori Hattori and Koji Kawai and Toru Shimazui and Hideyuki Akaza and Masayuki Yamamoto},
  journal={Cancer research},
  year={2004},
  volume={64 18},
  pages={6424-31}
}
The induction of phase 2 detoxifying enzymes, such as UDP-glucuronosyltransferases (UGTs), in response to an array of naturally occurring and synthetic agents, such as oltipraz (4-methyl-5-[2-pyrazinyl]-1,2-dithiole-3-thione), provides an effective means of protection against a variety of carcinogens. Transcription factor Nrf2 is an essential regulator of the inducible expression of detoxifying enzyme genes by chemopreventive agents. In this study, we investigated in Nrf2-deficient mice the… CONTINUE READING
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