Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals.

@article{Li2004Nrf2IA,
  title={Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals.},
  author={Ning Li and Jawed Alam and Mahalakshmi I. Venkatesan and Arantza Eiguren-Fernandez and Debra Schmitz and Emma Di Stefano and Ndaisha Slaughter and Erin Killeen and Xiaorong Wang and Aaron Huang and Meiying Wang and Antonio H. Miguel and Arthur Eung-Hyuck Cho and Constantinos Sioutas and Andr{\'e} E Nel},
  journal={Journal of immunology},
  year={2004},
  volume={173 5},
  pages={3467-81}
}
The proinflammatory effects of particulate pollutants, including diesel exhaust particles (DEP), are related to their content of redox cycling chemicals and their ability to generate oxidative stress in the respiratory tract. An antioxidant defense pathway, which involves phase II enzyme expression, protects against the pro-oxidative and proinflammatory effects of DEP. The expression of enzymes, including heme oxygenase-1 (HO-1) and GST, is dependent on the activity of a genetic antioxidant… CONTINUE READING
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