Nrf2 induces cisplatin resistance through activation of autophagy in ovarian carcinoma.


UNLABELLED Cisplatin resistance is a major problem affecting ovarian carcinoma treatment. NF-E2-related factor 2 (Nrf2), a nuclear transcription factor, plays an important role in chemotherapy resistance. However, the underlying mechanism by which Nrf2 mediates cisplatin chemoresistance is unclear. METHODS The human ovarian carcinoma cell line, A2780, and… (More)



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