Nrf2 deficiency improves glucose tolerance in mice fed a high-fat diet.

@article{Zhang2012Nrf2DI,
  title={Nrf2 deficiency improves glucose tolerance in mice fed a high-fat diet.},
  author={Y J Zhang and Kai Connie Wu and Jie Jerry Liu and Curtis D. Klaassen},
  journal={Toxicology and applied pharmacology},
  year={2012},
  volume={264 3},
  pages={305-14}
}
Nrf2, a master regulator of intracellular redox homeostasis, is indicated to participate in fatty acid metabolism in liver. However, its role in diet-induced obesity remains controversial. In the current study, genetically engineered Nrf2-null, wild-type (WT), and Nrf2-activated, Keap1-knockdown (K1-KD) mice were fed either a control or a high-fat Western diet (HFD) for 12 weeks. The results indicate that the absence or enhancement of Nrf2 activity did not prevent diet-induced obesity, had… CONTINUE READING