Nrf2 deficiency causes tooth decolourization due to iron transport disorder in enamel organ.

  title={Nrf2 deficiency causes tooth decolourization due to iron transport disorder in enamel organ.},
  author={Toru Yanagawa and Ken Itoh and Junya Uwayama and Yasuaki Shibata and Akira Yamaguchi and Tsuneyoshi Sano and Tetsuro Ishii and Hiroshi Yoshida and Masayuki Yamamoto},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  volume={9 7},
Rodents have brownish-yellow incisors whose colour represents their iron content. Iron is deposited into the mature enamel by ameloblasts that outline enamel surface of the teeth. Nrf2 is a basic region-leucine zipper type transcription factor that regulates expression of a range of cytoprotective genes in response to oxidative and xenobiotic stresses. We found that genetically engineered Nrf2-deficient mice show decolourization of the incisors. While incisors of wild-type mice were brownish… CONTINUE READING


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