Nrf2 and the promotion of atherosclerosis:lessons to be learned

@article{Araujo2012Nrf2AT,
  title={Nrf2 and the promotion of atherosclerosis:lessons to be learned},
  author={Jesus A. Araujo},
  journal={Clinical Lipidology},
  year={2012},
  volume={7},
  pages={123 - 126}
}
  • Jesus A. Araujo
  • Published 2012
  • Medicine
  • Clinical Lipidology
    • Abstract ,...it seems clear that Nrf2 expression can promote atherosclerosis via systemic and/or vascular local effects... despite its antioxidant actions. Therefore, should the strategy to boost endogenous antioxidant protection via Nrf2 expression be abandoned?- 
    View on Taylor & Francis
    8 Citations
    Highly Influential Citations
    1
    Background Citations
    3

    Topics from this paper

    Explore Further: Topics Discussed in This Paper

        8 Citations
        Citation Type

        Citation Type

        Heme Oxygenase-1, Oxidation, Inflammation, and Atherosclerosis
        • 207
        • PDF
        Chronic Vascular Pathology and Toxicology
        • 1
        Prooxidative Effects of Ambient Pollutant Chemicals Are Inhibited by HDL
        • 20
        Genistein promotes the metabolic transformation of acetaminophen to glucuronic acid in human L-O2, HepG2 and Hep3b cells via the Nrf2/Keap1 pathway.
        • 9
        Particle-Induced Inflammation and Cardiovascular Diseases
        • 1
        Diesel exhaust particles and endothelial cells dysfunction: An update.
        • 26
        In silico modeling using in vitro high throughput screening data for toxicity prediction within REACH
        • PDF
        Inflammation, Aging, and Oxidative Stress
        • 10
        • Highly Influenced

        References

        SHOWING 1-10 OF 25 REFERENCES
        NF-E2–Related Factor 2 Promotes Atherosclerosis by Effects on Plasma Lipoproteins and Cholesterol Transport That Overshadow Antioxidant Protection
        • 124
        • PDF
        Disruption of Nrf2, a Key Inducer of Antioxidant Defenses, Attenuates ApoE-Mediated Atherosclerosis in Mice
        • 146
        • PDF
        Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element.
        • 875
        • PDF
        Nrf2 is essential for cholesterol crystal‐induced inflammasome activation and exacerbation of atherosclerosis
        • 204
        Nrf2-Keap1 defines a physiologically important stress response mechanism.
        • 1,299
        Role of Nrf2 in the Regulation of CD36 and Stress Protein Expression in Murine Macrophages: Activation by Oxidatively Modified LDL and 4-Hydroxynonenal
        • 346
        Nrf2 is essential for protection against acute pulmonary injury in mice.
        • K. Chan, Y. Kan
        • Biology, Medicine
        • Proceedings of the National Academy of Sciences of the United States of America
        • 1999
        • 555
        • PDF
        Transcription factor Nrf2 regulates SHP and lipogenic gene expression in hepatic lipid metabolism.
        • 137
        • PDF
        Antioxidant therapy and atherosclerosis: animal and human studies.
        • 55
        Role of oxidative modifications in atherosclerosis.
        • 2,337
        • PDF