Nrf2 and p53 cooperatively protect against BBN-induced urinary bladder carcinogenesis.

Abstract

Nuclear factor-erythroid 2 (NF-E2)-related factor 2 (Nrf2), a transcription factor that regulates inducible expression of detoxifying enzymes, is critical in preventing N-nitrosobutyl(4-hydroxybutyl)amine (BBN)-induced urinary bladder carcinogenesis. To explore whether Nrf2 and the tumor suppressor p53 cooperatively act in tumor prevention, we investigated… (More)

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Cite this paper

@article{Iida2007Nrf2AP, title={Nrf2 and p53 cooperatively protect against BBN-induced urinary bladder carcinogenesis.}, author={Katsuyuki Iida and Ken Itoh and Jonathan M. Maher and Yoshito Kumagai and Ryoichi Oyasu and Yukio Mori and Toru Shimazui and Hideyuki Akaza and Masayuki Yamamoto}, journal={Carcinogenesis}, year={2007}, volume={28 11}, pages={2398-403} }