Nrf2 and Notch Signaling in Lung Cancer: Near the Crossroad

@inproceedings{Sparaneo2016Nrf2AN,
  title={Nrf2 and Notch Signaling in Lung Cancer: Near the Crossroad},
  author={Angelo Sparaneo and F P Fabrizio and Lucia Anna Muscarella},
  booktitle={Oxidative medicine and cellular longevity},
  year={2016}
}
The transcription factor Nrf2 (NF-E2 related factor 2) is a master regulator of the cell antioxidant response associated with tumor growth and resistance to cytotoxic treatments. In particular, Nrf2 induces upregulation of cytoprotective genes by interacting with the closely situated AREs (Antioxidant Response Elements) in response to endogenous or exogenous stress stimuli and takes part to several oncogenic signaling pathways. Among these, the crosstalk with Notch pathway has been shown to… CONTINUE READING
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