Nrf2 activation protects the liver from ischemia/reperfusion injury in mice.

@article{Kudoh2014Nrf2AP,
  title={Nrf2 activation protects the liver from ischemia/reperfusion injury in mice.},
  author={Kazuhiro Kudoh and Hiroshi Uchinami and Masato Yoshioka and Ekihiro Seki and Yuzo Yamamoto},
  journal={Annals of surgery},
  year={2014},
  volume={260 1},
  pages={118-27}
}
OBJECTIVE To investigate the role of Nrf2 in the pathogenesis of hepatic ischemia-reperfusion (I/R) injury. BACKGROUND Hepatic I/R injury is a serious complication that leads to liver failure after liver surgery. NF-E2-related factor 2 (Nrf2) is a transcription factor that plays a critical role in protecting cells against oxidative stress. Therefore, it is suggested that Nrf2 activation protects the liver from I/R injury. METHODS Wild-type and Nrf2-deficient mice were treated with 15-deoxy… CONTINUE READING