Nrf2 activation: a potential strategy for the prevention of acute mountain sickness.

@article{Lisk2013Nrf2AA,
  title={Nrf2 activation: a potential strategy for the prevention of acute mountain sickness.},
  author={Christina Lisk and J M Mccord and Swapan Kumar Bose and T O'Moore Sullivan and Zoe L. Loomis and Eva Nozik-Grayck and Thies Schroeder and Karyn Hamilton and David C Irwin},
  journal={Free radical biology & medicine},
  year={2013},
  volume={63},
  pages={264-73}
}
Reactive oxygen species (ROS) formed during acute high altitude exposure contribute to cerebral vascular leak and development of acute mountain sickness (AMS). Nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2) is a transcription factor that regulates expression of greater than 90% of antioxidant genes, but prophylactic treatment with Nrf2 activators has not yet been tested as an AMS therapy. We hypothesized that prophylactic activation of the antioxidant genome with Nrf2 activators… CONTINUE READING