Nrf2-Keap1 antioxidant defense and cell survival signaling are upregulated by 17β-estradiol in homocysteine-treated dopaminergic SH-SY5Y cells.

@article{Chen2013Nrf2Keap1AD,
  title={Nrf2-Keap1 antioxidant defense and cell survival signaling are upregulated by 17β-estradiol in homocysteine-treated dopaminergic SH-SY5Y cells.},
  author={Cheng-Sheng Chen and Yu-Ting Tseng and Ya-Yun Hsu and Y C Lo},
  journal={Neuroendocrinology},
  year={2013},
  volume={97 3},
  pages={232-41}
}
BACKGROUND AND AIMS A recent neuroimaging study discovered the neurotoxicity effects of homocysteine (Hcy), which is only seen in elderly women. Estrogens exert a variety of actions on brain function that influence cognitive function, mood, and neuroprotection. The Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant defense pathway has been well-known to afford neuroprotection. Here, we first demonstrate the roles of Nrf2-Keap1 in 17… CONTINUE READING

8 Figures & Tables

Connections & Topics

Mentioned Connections BETA
Further , E2 decreased Hcy - induced apoptotic death by upregulating the antiapoptotic protein Bcl-2 , decreasing cytochrome c release from mitochondria , and attenuating apoptotic cascade activation ( Bax , caspase-9 , and caspase-3 ) .
Further , E2 decreased Hcy - induced apoptotic death by upregulating the antiapoptotic protein Bcl-2 , decreasing cytochrome c release from mitochondria , and attenuating apoptotic cascade activation ( Bax , caspase-9 , and caspase-3 ) .
All Topics