Nrf2 Activator RS9 Suppresses Pathological Ocular Angiogenesis and Hyperpermeability.

  title={Nrf2 Activator RS9 Suppresses Pathological Ocular Angiogenesis and Hyperpermeability.},
  author={Shinsuke Nakamura and Tetsuro Noguchi and Y. Inoue and Shuji Sakurai and Anri Nishinaka and Yoshifumi Hida and T. Masuda and Y. Nakagami and Naoto Horai and H. Tsusaki and H. Hara and M. Shimazawa},
  journal={Investigative ophthalmology & visual science},
  volume={60 6},
  • Shinsuke Nakamura, Tetsuro Noguchi, +9 authors M. Shimazawa
  • Published 2019
  • Medicine
  • Investigative ophthalmology & visual science
  • Purpose Ocular angiogenesis, including retinopathy of prematurity, diabetic retinopathy, and exudative age-related macular degeneration, are closely related to oxidative stress. Many reports have shown that the cellular protective mechanism against oxidative stress and inflammatory response has nuclear factor-erythroid 2-related factor-2 (Nrf2) activity. The aim of this study was to investigate the effectiveness and mechanism of Nrf2 activation in treating the ocular diseases with abnormal… CONTINUE READING
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