Nrf2--A regulator of keratinocyte redox signaling.

  title={Nrf2--A regulator of keratinocyte redox signaling.},
  author={Matthias Schaefer and Sabine Werner},
  journal={Free radical biology & medicine},
  volume={88 Pt B},
The skin is frequently exposed to environmental challenges, such as UV irradiation, toxic chemicals, and mechanical wounding. These insults cause an increase in the levels of reactive oxygen species, resulting in oxidative stress and concomitant inflammation, skin aging, and even cancer development. Therefore, an efficient antioxidant defense strategy is of major importance in this tissue. Since the Nrf2 transcription factor regulates a battery of genes involved in the defense against reactive… CONTINUE READING
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