Nrf2: friend and foe in preventing cigarette smoking-dependent lung disease.

@article{Mller2012Nrf2FA,
  title={Nrf2: friend and foe in preventing cigarette smoking-dependent lung disease.},
  author={Thomas M{\"u}ller and Arnd Hengstermann},
  journal={Chemical research in toxicology},
  year={2012},
  volume={25 9},
  pages={1805-24}
}
Chronic exposure to cigarette smoke (CS) generally confronts cellular defense systems with one of the strongest known environmental challenges. In particular, the continuous exposure of tissues of the respiratory tract to abundant concentrations of radicals; volatile compounds of the gas phase, mainly reactive oxygen and nitrogen species; and CS condensate deposits trigger a pleiotropic adaptive response, generally aimed at restoring tissue homeostasis. As documented by numerous studies… CONTINUE READING

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