Nrf2/HO-1 signaling pathway may be the prime target for chemoprevention of cisplatin-induced nephrotoxicity by lycopene.

@article{Sahin2010Nrf2HO1SP,
  title={Nrf2/HO-1 signaling pathway may be the prime target for chemoprevention of cisplatin-induced nephrotoxicity by lycopene.},
  author={Kazim Sahin and Mehmet Tuzcu and Nurhan Şahin and Shakir Ali and Omer N Kucuk},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2010},
  volume={48 10},
  pages={2670-4}
}
Cisplatin is used against various types of solid tumors. However, its use is limited by its nephrotoxicity, with about 25-35% patients experiencing a significant decline in renal function after a single dose of cisplatin. This study reports that lycopene mitigates the nephrotoxic effect of cisplatin in rat through Nrf2-mediated induction of heme oxygenase-1 (HO-1). Eight weeks old male rats (200-215 g) were supplemented with lycopene complex containing 6% lycopene, 1.5% tocopherols, 1% phytoene… CONTINUE READING
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