Nrf2/ARE regulated antioxidant gene expression in endothelial and smooth muscle cells in oxidative stress: implications for atherosclerosis and preeclampsia.

@article{Mann2007Nrf2ARERA,
  title={Nrf2/ARE regulated antioxidant gene expression in endothelial and smooth muscle cells in oxidative stress: implications for atherosclerosis and preeclampsia.},
  author={Giovanni E. Mann and J{\"o}rg Niehueser-Saran and Alan E. Watson and Ling Gao and Tetsuro Ishii and Patricia de Winter and Richard C. M. Siow},
  journal={Sheng li xue bao : [Acta physiologica Sinica]},
  year={2007},
  volume={59 2},
  pages={117-27}
}
Increased generation of reactive oxygen species (ROS) in vascular diseases such as atherosclerosis, diabetes, chronic renal failure and preeclampsia readily leads to impaired endothelium-dependent relaxation and vascular injury. To counteract ROS- and electrophile-mediated injury, cells can induce a number of genes encoding phase II detoxifying enzymes and antioxidant proteins. A cis-acting transcriptional regulatory element, designated as antioxidant response element (ARE) or electrophile… CONTINUE READING

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