Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs.

  title={Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs.},
  author={Takumi Satoh and Scott R Mckercher and Stuart Lipton},
  journal={Free radical biology & medicine},
Living cells maintain a balance between oxidation and reduction, and perturbations of this redox balance are thought to contribute to various diseases. Recent attempts to regulate redox state have focused on electrophiles (EPs), which activate potent cellular defense systems against oxidative stress. One example of this approach is exemplified by carnosic acid (CA) and carnosol (CS), compounds that are found in the herb rosemary (Rosmarinus officinalis). Importantly, CA and CS themselves are… CONTINUE READING