• Corpus ID: 13142671

Nrf2, a master regulator of detoxification and also antioxidant, anti-inflammatory and other cytoprotective mechanisms, is raised by health promoting factors.

  title={Nrf2, a master regulator of detoxification and also antioxidant, anti-inflammatory and other cytoprotective mechanisms, is raised by health promoting factors.},
  author={Martin L. Pall and Stephen A. Levine},
  journal={Sheng li xue bao : [Acta physiologica Sinica]},
  volume={67 1},
  • M. Pall, S. Levine
  • Published 25 February 2015
  • Medicine
  • Sheng li xue bao : [Acta physiologica Sinica]
The transcription factor Nrf2, nuclear factor erythroid-2-related factor 2, activates the transcription of over 500 genes in the human genome, most of which have cytoprotective functions. Nrf2 produces cytoprotection by detoxification mechanisms leading to increased detoxification and excretion of both organic xenobiotics and toxic metals; its action via over two dozen genes increases highly coordinated antioxidant activities; it produces major anti-inflammatory changes; it stimulates… 

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