• Corpus ID: 13142671

Nrf2, a master regulator of detoxification and also antioxidant, anti-inflammatory and other cytoprotective mechanisms, is raised by health promoting factors.

@article{Pall2015Nrf2AM,
  title={Nrf2, a master regulator of detoxification and also antioxidant, anti-inflammatory and other cytoprotective mechanisms, is raised by health promoting factors.},
  author={Martin L. Pall and Stephen A. Levine},
  journal={Sheng li xue bao : [Acta physiologica Sinica]},
  year={2015},
  volume={67 1},
  pages={
          1-18
        }
}
  • M. Pall, S. Levine
  • Published 25 February 2015
  • Medicine
  • Sheng li xue bao : [Acta physiologica Sinica]
The transcription factor Nrf2, nuclear factor erythroid-2-related factor 2, activates the transcription of over 500 genes in the human genome, most of which have cytoprotective functions. Nrf2 produces cytoprotection by detoxification mechanisms leading to increased detoxification and excretion of both organic xenobiotics and toxic metals; its action via over two dozen genes increases highly coordinated antioxidant activities; it produces major anti-inflammatory changes; it stimulates… 

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References

SHOWING 1-10 OF 149 REFERENCES
Targeting Nrf2-Mediated Gene Transcription by Triterpenoids and Their Derivatives
TLDR
Data from in vitro and in vivo experiments strongly suggest synthetic derivatives as promising candidates in the chemopreventive and chemotherapeutic strategies.
Nrf2/ARE regulated antioxidant gene expression in endothelial and smooth muscle cells in oxidative stress: implications for atherosclerosis and preeclampsia.
TLDR
The evidence that the Nrf2/ARE signaling pathway plays an important role in vascular homeostasis and the defense of endothelial and smooth muscle cells against sustained oxidative stress associated with diseases such as atherosclerosis and preeclampsia is reviewed.
The cytoprotective role of the Keap1–Nrf2 pathway
TLDR
Cross-talks with other signalling pathways broadens the role of the Keap1–Nrf2 pathway in determining the fate of the cell, impacting fundamental biological processes such as proliferation, apoptosis, angiogenesis and metastasis.
Effect of diallyl sulfide on in vitro and in vivo Nrf2-mediated pulmonic antioxidant enzyme expression via activation ERK/p38 signaling pathway.
TLDR
It is demonstrated that DAS administration can significantly induce the activity of antioxidant enzymes in rat lungs and a possible use for DAS as a dietary preventive agent against oxidative stress-induced lung injury is suggested.
The crosstalk between Nrf2 and AMPK signal pathways is important for the anti-inflammatory effect of berberine in LPS-stimulated macrophages and endotoxin-shocked mice.
TLDR
The results demonstrate convergence between AMPK and Nrf2 pathways and this intersection is essential for anti-inflammatory effect of BBR in LPS-stimulated macrophages and endotoxin-shocked mice.
Nrf2, a guardian of healthspan and gatekeeper of species longevity.
TLDR
It is hypothesize that this signaling pathway plays a critical role in the determination of species longevity and that this pathway may indeed be the master regulator of the aging process.
...
...