Nrbf2 protein suppresses autophagy by modulating Atg14L protein-containing Beclin 1-Vps34 complex architecture and reducing intracellular phosphatidylinositol-3 phosphate levels.

@article{Zhong2014Nrbf2PS,
  title={Nrbf2 protein suppresses autophagy by modulating Atg14L protein-containing Beclin 1-Vps34 complex architecture and reducing intracellular phosphatidylinositol-3 phosphate levels.},
  author={Yu Zhong and Deanna H. Morris and Lin Lin Jin and Mittul S. Patel and Senthil Kumar Karunakaran and You-Jun Fu and Emily A. Matuszak and H Lorraine Weiss and Brian T Chait and Qing Wang},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 38},
  pages={
          26021-37
        }
}
Autophagy is a tightly regulated lysosomal degradation pathway for maintaining cellular homeostasis and responding to stresses. Beclin 1 and its interacting proteins, including the class III phosphatidylinositol-3 kinase Vps34, play crucial roles in autophagy regulation in mammals. We identified nuclear receptor binding factor 2 (Nrbf2) as a Beclin 1-interacting protein from Becn1(-/-);Becn1-EGFP/+ mouse liver and brain. We also found that Nrbf2-Beclin 1 interaction required the N terminus of… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 16 CITATIONS

Beclin 1-Vps34 complex architecture: Understanding the nuts and bolts of therapeutic targets

VIEW 21 EXCERPTS
CITES BACKGROUND, RESULTS & METHODS
HIGHLY INFLUENCED

A molecular perspective of mammalian autophagosome biogenesis

  • The Journal of biological chemistry
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND