Nras loss induces metastatic conversion of Rb1-deficient neuroendocrine thyroid tumor

  title={Nras loss induces metastatic conversion of Rb1-deficient neuroendocrine thyroid tumor},
  author={Chiaki Takahashi and Bernardo Contreras and Tsuyoshi Iwanaga and Yujiro Takegami and Anke Bakker and Roderick Terry Bronson and Makoto Noda and Massimo F. Loda and Jennifer Leigh Hunt and Mark E. Ewen},
  journal={Nature Genetics},
Mutations in the gene encoding the retinoblastoma tumor suppressor predispose humans and mice to tumor development. Here we have assessed the effect of Nras loss on tumor development in Rb1 heterozygous mice. Loss of one or two Nras alleles is shown to significantly reduce the severity of pituitary tumors arising in Rb1+/− animals by enhancing their differentiation. By contrast, C-cell thyroid adenomas occurring in Rb1+/− mice progress to metastatic medullary carcinomas after loss of Nras. In… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 31 references

Cell type-specific effects of Rb deletion in the murine retina

D MacPherson
Genes Dev • 2004

The Mouse (ed

Capen, C. C. et al. in International Classification of Roden Tumors
Mohr, U.) 269–322 • 2001

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