Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport.

@article{Fleming1998Nramp2IM,
  title={Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport.},
  author={Mark D Fleming and M A Romano and Maureen A Su and Laura M. Garrick and Michael D. Garrick and Nancy Catherine Andrews},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 3},
  pages={1148-53}
}
The Belgrade (b) rat has an autosomal recessively inherited, microcytic, hypochromic anemia associated with abnormal reticulocyte iron uptake and gastrointestinal iron absorption. The b reticulocyte defect appears to be failure of iron transport out of endosomes within the transferrin cycle. Aspects of this phenotype are similar to those reported for the microcytic anemia (mk) mutation in the mouse. Recently, mk has been attributed to a missense mutation in the gene encoding the putative iron… CONTINUE READING
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Fleming et al

  • E. W. Randell, J. G. Parkes, +8 authors are discussed in the text. 1152 Genetics
  • Proc. Natl. Acad. Sci. USA 95
  • 1998

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