Nramp1 expression by dendritic cells modulates inflammatory responses during Salmonella Typhimurium infection.

@article{Valdez2008Nramp1EB,
  title={Nramp1 expression by dendritic cells modulates inflammatory responses during Salmonella Typhimurium infection.},
  author={Yanet Valdez and Gretchen E. Diehl and Bruce A Vallance and Guntram Grassl and Julian Andrew Guttman and Nat F. Brown and Carrie M. Rosenberger and Dan R. Littman and Philippe Gros and Brett B. Finlay},
  journal={Cellular microbiology},
  year={2008},
  volume={10 8},
  pages={1646-61}
}
Host resistance against Salmonella enterica serovar Typhimurium (S. Typhimurium) is mediated by natural resistance-associated macrophage protein 1 (Nramp1/Slc11a1). Nramp1 is critical to host defence, as mice lacking Nramp1 fail to control bacterial replication and succumb to low doses of S. Typhimurium. Despite this crucial role, the mechanisms underlying Nramp1's protective effects are unclear. Dendritic cells (DCs) that sample the intestinal lumen are among the first cells encountered by S… CONTINUE READING
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