Nramp1 and NrampB Contribute to Resistance against Francisella in Dictyostelium

  title={Nramp1 and NrampB Contribute to Resistance against Francisella in Dictyostelium},
  author={Yannick Brenz and Denise Ohnezeit and Hanne Cecilie Winther-Larsen and Monica Hagedorn},
  booktitle={Front. Cell. Infect. Microbiol.},
The Francisella genus comprises highly pathogenic bacteria that can cause fatal disease in their vertebrate and invertebrate hosts including humans. In general, Francisella growth depends on iron availability, hence, iron homeostasis must be tightly regulated during Francisella infection. We used the system of the professional phagocyte Dictyostelium and the fish pathogen F. noatunensis subsp. noatunensis (F.n.n.) to investigate the role of the host cell iron transporters Nramp (natural… CONTINUE READING


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