Npp1 promotes atherosclerosis in ApoE knockout mice

@inproceedings{Nitschke2011Npp1PA,
  title={Npp1 promotes atherosclerosis in ApoE knockout mice},
  author={Yvonne Nitschke and Gabriele Weissen-Plenz and Robert Terkeltaub and Frank Rutsch},
  booktitle={Journal of cellular and molecular medicine},
  year={2011}
}
Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) generates inorganic pyrophosphate (PP(i)), a physiologic inhibitor of hydroxyapatite deposition. In a previous study, we found NPP1 expression to be inversely correlated with the degree of atherosclerotic plaque calcification. Moreover, function-impairing mutations of ENPP1, the gene encoding for NPP1, are associated with severe, artery tunica media calcification and myointimal hyperplasia with infantile onset in human beings. NPP1 and… CONTINUE READING

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