Npgrj_NCHEMBIO_128 26..28

Abstract

Fluorination has gained an increasingly important role in drug discovery and development. Here we describe a versatile strategy that combines cytochrome P450–catalyzed oxygenation with deoxofluorination to achieve monoand polyfluorination of nonreactive sites in a variety of organic scaffolds. This procedure was applied for the rapid identification of fluorinated drug derivatives with enhanced membrane permeability.

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Cite this paper

@inproceedings{Rentmeister2008Npgrj_NCHEMBIO_1282, title={Npgrj_NCHEMBIO_128 26..28}, author={Andrea Rentmeister and Frances H. Arnold and Rudi Fasan}, year={2008} }