Npas4, a novel helix–loop–helix PAS domain protein, is regulated in response to cerebral ischemia

  title={Npas4, a novel helix–loop–helix PAS domain protein, is regulated in response to cerebral ischemia},
  author={M. Shamloo and L. Soriano and D. von Schack and Mattias Rickhag and Daniel J Chin and M. Gonzalez-Zulueta and Gunilla Gido and R. Urfer and T. Wieloch and K. Nikolich},
  journal={European Journal of Neuroscience},
  • M. Shamloo, L. Soriano, +7 authors K. Nikolich
  • Published 2006
  • Biology, Medicine
  • European Journal of Neuroscience
  • Basic helix–loop–helix PAS domain proteins form a growing family of transcription factors. These proteins are involved in the process of adaptation to cellular stresses and environmental factors such as a change in oxygen concentration. We describe the identification and characterization of a recently cloned PAS domain protein termed Npas4 in ischemic rat brain. Using gene expression profiling following middle cerebral artery occlusion, we showed that the Npas4 mRNA is differentially expressed… CONTINUE READING
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