Npas4, a novel helix–loop–helix PAS domain protein, is regulated in response to cerebral ischemia

@article{Shamloo2006Npas4AN,
  title={Npas4, a novel helix–loop–helix PAS domain protein, is regulated in response to cerebral ischemia},
  author={M. Shamloo and L. Soriano and D. von Schack and Mattias Rickhag and Daniel J Chin and M. Gonzalez-Zulueta and Gunilla Gido and R. Urfer and T. Wieloch and K. Nikolich},
  journal={European Journal of Neuroscience},
  year={2006},
  volume={24}
}
  • M. Shamloo, L. Soriano, +7 authors K. Nikolich
  • Published 2006
  • Biology, Medicine
  • European Journal of Neuroscience
  • Basic helix–loop–helix PAS domain proteins form a growing family of transcription factors. These proteins are involved in the process of adaptation to cellular stresses and environmental factors such as a change in oxygen concentration. We describe the identification and characterization of a recently cloned PAS domain protein termed Npas4 in ischemic rat brain. Using gene expression profiling following middle cerebral artery occlusion, we showed that the Npas4 mRNA is differentially expressed… CONTINUE READING
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    References

    SHOWING 1-10 OF 39 REFERENCES
    LE-PAS, a novel Arnt-dependent HLH-PAS protein, is expressed in limbic tissues and transactivates the CNS midline enhancer element.
    • 34
    • Highly Influential
    Identification of a Novel Basic Helix-Loop-Helix-PAS Factor, NXF, Reveals a Sim2 Competitive, Positive Regulatory Role in Dendritic-Cytoskeleton Modulator Drebrin Gene Expression
    • 110
    • Highly Influential
    • PDF
    Hypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction.
    • 138
    Temporal and spatial gene expression patterns after experimental stroke in a rat model and characterization of PC4, a potential regulator of transcription
    • 43
    A role for receptor tyrosine phosphataseζ in glioma cell migration
    • 93
    • PDF
    Hypoxia‐induced activation of HIF‐1: role of HIF‐1α‐Hsp90 interaction
    • 250
    Altered gene expression in brain ischemia.
    • 159
    Nxf and Fbxo33: novel seizure‐responsive genes in mice
    • 46
    • Highly Influential