Noxious-evoked c-fos expression in brainstem neurons immunoreactive for GABAB, mu-opioid and NK-1 receptors.

@article{Pinto2003NoxiousevokedCE,
  title={Noxious-evoked c-fos expression in brainstem neurons immunoreactive for GABAB, mu-opioid and NK-1 receptors.},
  author={Marta Pinto and Deolinda Lima and Jos{\'e} Manuel Castro-Lopes and Isaura Tavares},
  journal={The European journal of neuroscience},
  year={2003},
  volume={17 7},
  pages={1393-402}
}
Modulation of nociceptive transmission at the brainstem involves several neurochemical systems. The precise location and specific characteristics of nociceptive neurons activated in each system was never reported. In this study, the presence of GABA(B), mu-opioid, and neurokinin-1 (NK-1) receptors in brainstem nociceptive neurons was investigated by double-immunocytochemical detection of each receptor and noxious-evoked induction of the c-fos proto-oncogene. Noxious cutaneous mechanical… CONTINUE READING
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