Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines

@article{Macpherson2007NoxiousCA,
  title={Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines},
  author={Lindsey J. Macpherson and Adrienne E. Dubin and Michael John Christopher Evans and Felix Marr and Peter G. Schultz and Benjamin F. Cravatt and Ardem Patapoutian},
  journal={Nature},
  year={2007},
  volume={445},
  pages={541-545}
}
The nervous system senses peripheral damage through nociceptive neurons that transmit a pain signal. TRPA1 is a member of the Transient Receptor Potential (TRP) family of ion channels and is expressed in nociceptive neurons. TRPA1 is activated by a variety of noxious stimuli, including cold temperatures, pungent natural compounds, and environmental irritants. How such diverse stimuli activate TRPA1 is not known. We observed that most compounds known to activate TRPA1 are able to covalently bind… 
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