Noxious cold stimulation induces mitogen-activated protein kinase activation in transient receptor potential (TRP) channels TRPA1- and TRPM8-containing small sensory neurons.

@article{Mizushima2006NoxiousCS,
  title={Noxious cold stimulation induces mitogen-activated protein kinase activation in transient receptor potential (TRP) channels TRPA1- and TRPM8-containing small sensory neurons.},
  author={Toshiyuki Mizushima and Koichi Obata and Hirokazu Katsura and Hiroki Yamanaka and Kimiko Kobayashi and Yi Dai and T OSHIHIRO O DA Fukuoka and Atsushi Tokunaga and Takashi Mashimo and Koichi Noguchi},
  journal={Neuroscience},
  year={2006},
  volume={140 4},
  pages={1337-48}
}
Two cold-sensitive transient receptor potential (TRP) channels, TRPA1 and TRPM8, have been identified and considered interesting because of their possible roles in thermosensation, nociception and other functions. Recently, we have reported that the phosphorylation of extracellular signal-regulated protein kinase and p38 mitogen-activated protein kinase occurred in primary afferent neurons in response to noxious heat stimulation of the peripheral tissue, i.e. activity-dependent activation of… CONTINUE READING