Nox4 is a novel inducible source of reactive oxygen species in monocytes and macrophages and mediates oxidized low density lipoprotein-induced macrophage death.

@article{Lee2010Nox4IA,
  title={Nox4 is a novel inducible source of reactive oxygen species in monocytes and macrophages and mediates oxidized low density lipoprotein-induced macrophage death.},
  author={Chi Fung Lee and Mu Qiao and Katrin Schroeder and Qingwei Zhao and Reto H Asmis},
  journal={Circulation research},
  year={2010},
  volume={106 9},
  pages={1489-97}
}
RATIONALE The enhanced formation of intracellular reactive oxygen species (ROS) induced by oxidized low-density lipoprotein (OxLDL) promotes macrophage death, a process likely to contribute to the formation of necrotic cores and the progression of atherosclerotic lesions. Yet macrophage deficiency of phagocytic NADPH oxidase (Nox2), the primary source of ROS in macrophages, does not reduce atherosclerotic lesion development in mice. This suggests an as yet unidentified NADPH oxidase may be… CONTINUE READING

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