Nox4 contributes to the hypoxia-mediated regulation of actin cytoskeleton in cerebrovascular smooth muscle.

@article{Coucha2016Nox4CT,
  title={Nox4 contributes to the hypoxia-mediated regulation of actin cytoskeleton in cerebrovascular smooth muscle.},
  author={Maha Coucha and Mohammed A. Abdelsaid and Weiguo Li and Maribeth H. Johnson and L{\'a}szl{\'o} Őrfi and Azza B El-Remessy and Susan C Fagan and Adviye Ergul},
  journal={Life sciences},
  year={2016},
  volume={163},
  pages={46-54}
}
UNLABELLED Ischemia/reperfusion and the resulting oxidative/nitrative stress impair cerebral myogenic tone via actin depolymerization. While it is known that NADPH oxidase (Nox) family is a major source of vascular oxidative stress; the extent and mechanisms by which Nox activation contributes to actin depolymerization, and equally important, the relative role of Nox isoforms in this response is not clear. AIM To determine the role of Nox4 in hypoxia-mediated actin depolymerization and… CONTINUE READING