Nox4 and redox signaling mediate TGF-β-induced endothelial cell apoptosis and phenotypic switch

Abstract

Transforming growth factor-β (TGF-β) triggers apoptosis in endothelial cells, while the mechanisms underlying this action are not entirely understood. Using genetic and pharmacological tools, we demonstrated that TGF-β induced a moderate apoptotic response in human cultured endothelial cells, which was dependent upon upregulation of the Nox4 NADPH oxidase… (More)
DOI: 10.1038/cddis.2013.551

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