Nox4 and nox2 NADPH oxidases mediate distinct cellular redox signaling responses to agonist stimulation.

@article{Anilkumar2008Nox4AN,
  title={Nox4 and nox2 NADPH oxidases mediate distinct cellular redox signaling responses to agonist stimulation.},
  author={Narayana P. Anilkumar and Roberta J Weber and Min Zhang and Alison C. Brewer and Ajay M. Shah},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2008},
  volume={28 7},
  pages={1347-54}
}
OBJECTIVE The NADPH oxidase isoforms Nox2 and Nox4 are coexpressed in many cell types and are implicated in agonist-stimulated redox-sensitive signal transduction. We compared the involvement of Nox2 versus Nox4 in redox-sensitive protein kinase activation after agonist stimulation. METHODS AND RESULTS We transfected HEK293 cells with Nox2 or Nox4 and compared ROS production and activation of mitogen activated protein kinases (MAPKs), Akt, and GSK3beta after acute agonist stimulation. Nox4… CONTINUE READING