Nox2-derived reactive oxygen species mediate neurovascular dysregulation in the aging mouse brain.

@article{Park2007Nox2derivedRO,
  title={Nox2-derived reactive oxygen species mediate neurovascular dysregulation in the aging mouse brain.},
  author={Laibaik Park and Josef Anrather and H{\'e}l{\`e}ne Girouard and Ping Zhou and C Iadecola},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2007},
  volume={27 12},
  pages={1908-18}
}
Aging is associated with cerebrovascular dysregulation, which may underlie the increased susceptibility to ischemic stroke and vascular cognitive impairment occurring in the elder individuals. Although it has long been known that oxidative stress is responsible for the cerebrovascular dysfunction, the enzymatic system(s) generating the reactive oxygen species (ROS) have not been identified. In this study, we investigated whether the superoxide-producing enzyme NADPH oxidase is involved in… CONTINUE READING

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