Nox2-dependent glutathionylation of endothelial NOS leads to uncoupled superoxide production and endothelial barrier dysfunction in acute lung injury.

@article{Wu2014Nox2dependentGO,
  title={Nox2-dependent glutathionylation of endothelial NOS leads to uncoupled superoxide production and endothelial barrier dysfunction in acute lung injury.},
  author={Feng Wu and William S Szczepaniak and Sruti S. Shiva and Huanbo Liu and Yinna Wang and Ling Wang and Ying K. Wang and Eric E. Kelley and Alex F. Chen and Mark T Gladwin and Bryan J McVerry},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2014},
  volume={307 12},
  pages={L987-97}
}
Microvascular barrier integrity is dependent on bioavailable nitric oxide (NO) produced locally by endothelial NO synthase (eNOS). Under conditions of limited substrate or cofactor availability or by enzymatic modification, eNOS may become uncoupled, producing superoxide in lieu of NO. This study was designed to investigate how eNOS-dependent superoxide production contributes to endothelial barrier dysfunction in inflammatory lung injury and its regulation. C57BL/6J mice were challenged with… CONTINUE READING
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