Nox2-containing NADPH oxidase and Akt activation play a key role in angiotensin II-induced cardiomyocyte hypertrophy.

@article{Hingtgen2006Nox2containingNO,
  title={Nox2-containing NADPH oxidase and Akt activation play a key role in angiotensin II-induced cardiomyocyte hypertrophy.},
  author={Shawn D Hingtgen and Xin Tian and Jusan Yang and Shannon M. Dunlay and Andrew S. Peek and Yihe Wu and Ram V. Sharma and John F. Engelhardt and Robin L. Davisson},
  journal={Physiological genomics},
  year={2006},
  volume={26 3},
  pages={180-91}
}
Angiotensin II (ANG II) has profound effects on the development and progression of pathological cardiac hypertrophy; however, the intracellular signaling mechanisms are not fully understood. In this study, we used genetic tools to test the hypothesis that increased formation of superoxide (O2-*) radicals from a Rac1-regulated Nox2-containing NADPH oxidase is a key upstream mediator of ANG II-induced activation of serine-threonine kinase Akt, and that this signaling cascade plays a crucial role… CONTINUE READING

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Morphological, biochemical, and electrophysiological charac 189 NOX2-MEDIATED CARDIOMYOCYTE HYPERTROPHY Physiol Genomics

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